Viking Therapeutics Nears Major Milestone for Game-Changing Oral Obesity Pill
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- October 23, 2025
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Excitement is building in the pharmaceutical world as Viking Therapeutics (VKTX) announces it is on track to complete enrollment for its crucial Phase 2 VENTURE study of VK2735, its groundbreaking oral obesity drug candidate, by the fourth quarter of this year. This eagerly awaited milestone signals a significant leap forward in the quest for more accessible and convenient weight management solutions.
VK2735 is an innovative, dual GLP-1/GIP receptor agonist, a class of drugs that has already shown immense promise in combating obesity and its related metabolic conditions.
What sets VK2735 apart, and what makes this upcoming enrollment completion so pivotal, is its oral formulation. Imagine the convenience of a pill compared to frequent injections – this could be a true game-changer for millions seeking effective weight loss treatments.
The anticipation is not unfounded.
Earlier Phase 1 results for VK2735 were nothing short of impressive, demonstrating robust efficacy. Participants in the Phase 1 trial experienced a mean weight loss of up to 5.3% from baseline over just 28 days, and an even more remarkable 7.1% when adjusted for placebo. These early findings strongly suggest that VK2735 possesses the potency required to make a substantial impact on obesity, a global health challenge.
Viking Therapeutics is strategically positioning VK2735 to compete directly with leading injectable treatments already on the market, such as Novo Nordisk's Wegovy and Eli Lilly's Zepbound.
While these injectables have revolutionized obesity care, an effective oral alternative could significantly expand market reach and improve patient adherence due to its ease of administration.
Beyond the oral formulation, Viking also has an injectable version of VK2735 (VK2735 SC) that has shown even more dramatic results, with up to 14.7% weight loss observed at 13 weeks in its own Phase 2 study.
This dual approach underscores Viking's comprehensive strategy in tackling obesity from multiple angles, offering diverse solutions to patients and clinicians.
As the Q4 enrollment completion approaches, all eyes will be on Viking Therapeutics. Successful completion of the VENTURE study and subsequent positive data could solidify VK2735's position as a formidable contender in the rapidly expanding and highly competitive obesity drug market.
For those grappling with weight management, the prospect of an effective and convenient oral therapy brings renewed hope and excitement.
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