Unleash the Beast: Why Deebo Samuel & Brandon Aiyuk Are Your Must-Play WRs for 49ers DFS in Week 5!
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- October 03, 2025
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The San Francisco 49ers' receiving corps is facing a significant shake-up in Week 5, presenting a golden opportunity for savvy DFS players. With promising rookie Ricky Pearsall and reliable veteran Jauan Jennings both sidelined, the target tree for quarterback Brock Purdy is about to get much, much narrower.
This isn't just a minor adjustment; it's a neon sign pointing directly to the team's undisputed star wideouts, Deebo Samuel and Brandon Aiyuk.
The absence of Pearsall, a recent draft pick expected to contribute, and Jennings, a key blocker and third-down option, means a substantial void in targets that must be filled.
For Daily Fantasy Sports purposes, this is fantastic news. More targets mean more opportunities for receptions, yards, and ultimately, fantasy points. The primary beneficiaries? None other than the dynamic duo of Deebo Samuel and Brandon Aiyuk, who are now poised for an even larger share of the offensive pie.
Deebo Samuel is a bona fide fantasy cheat code when given the volume.
His unique 'wide back' role allows him to rack up points through both receiving and rushing, making him an incredibly high-ceiling play. With fewer mouths to feed, expect Kyle Shanahan to creatively scheme touches for Samuel, leveraging his elite YAC (Yards After Catch) ability and physical play style.
He thrives on volume, and Week 5 is setting up to deliver just that, positioning him as a strong candidate for a monstrous DFS performance.
Not to be outdone, Brandon Aiyuk has proven himself as a precise route-runner and a consistent big-play threat. His ability to win contested catches and stretch the field will be crucial, especially with additional targets coming his way.
As arguably the team's primary outside receiver, Aiyuk stands to inherit a significant portion of the vacated downfield targets. His strong rapport with Purdy is undeniable, and a concentrated passing game funnels even more looks his way, giving him a robust floor with plenty of upside for explosive plays.
For Week 5, the calculus is clear.
While both Samuel and Aiyuk were already strong plays, their DFS stock skyrockets with Pearsall and Jennings out of the picture. Depending on your roster construction and salary cap, targeting one or even both could be a game-winning strategy. Samuel offers the multi-faceted upside and rushing floor, while Aiyuk provides steady, high-volume receiving with big-play potential.
The limited options elevate both of them into must-consider territory for your lineups.
Don't overthink it. The 49ers' receiving situation for Week 5 is a clear-cut case of opportunity meeting talent. With Ricky Pearsall and Jauan Jennings watching from the sidelines, Deebo Samuel and Brandon Aiyuk are poised to dominate the target share and deliver a fantasy feast.
Lock them into your DFS lineups and prepare for a potential Week 5 explosion!
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