Patriots vs. Seahawks Week 1 Betting Odds: Spread, Moneyline & Over/Under Explained

When the NFL kicks off this season, the first headline‑making matchup pits the Seattle Seahawks against the New England Patriots at Lumen Field. The game starts at 5:20 p.m. Mountain (8:20 p.m. Eastern) on Wednesday, Sept. 9, and you can catch it on NBC or stream it via Peacock.

BetMGM’s sportsbook has the Seahawks nudged just ahead by three and a half points. In plain language, Seattle is a 3.5‑point favorite – a modest edge, but one that could easily swing with a single big play.

If you prefer straight‑up betting, the moneyline reflects Seattle’s status as the stronger side: the Seahawks sit at -200, meaning a $200 wager would net $100 profit if they win. The Patriots, on the other hand, are listed at +165, so a $100 bet on New England could bring in $165 if the underdogs pull off the upset.

For those who like the totals game, the over/under is set at 44.5 points. Expect a fairly tight defensive battle, but with enough firepower on both sides to keep the score hovering around the middle of that range.

All told, the odds suggest a competitive opener, and the betting lines give you several ways to get involved—whether you’re backing the home team, backing the underdog, or just trying to guess whether the combined score will break 45.

Remember, betting should always be done responsibly. If you need help, resources are available through the National Council on Problem Gambling.