Friday's MLB Showdown: Cardinals vs. Brewers — A Deep Dive into Betting Picks and Predictions!

As Friday, September 19, 2025, rolls around, baseball fans and bettors alike turn their attention to a compelling National League Central clash: the St. Louis Cardinals hosting the Milwaukee Brewers. This pivotal matchup not only carries significant divisional implications but also offers some tantalizing opportunities for those looking to place a wager.

Let's break down the dynamics of this game, focusing on key pitching matchups, recent form, and the most promising betting angles.

The mound will feature a fascinating contrast in styles. For the St. Louis Cardinals, veteran right-hander Sonny Gray is set to toe the rubber. Gray has been a picture of consistency this season, boasting a sterling 2.65 ERA through 28 starts, accumulating 185 strikeouts over 169.2 innings.

His ability to limit hard contact and command the strike zone makes him a formidable opponent for any lineup. The Cardinals have enjoyed a strong run with Gray on the mound, winning five of his last six starts, including a particularly dominant outing where he held the Brewers to just one run over seven innings.

Conversely, the Milwaukee Brewers will counter with right-hander Tobias Myers.

Myers, a younger arm, has shown flashes of brilliance but also periods of vulnerability. His 5.10 ERA over 16 starts reflects a pitcher who is still finding his rhythm at the major league level. While he possesses potential, his outings have often been characterized by allowing significant home run totals, a concerning trend when facing a Cardinals lineup that, despite its overall offensive struggles, can still generate power.

In his most recent start against St. Louis, Myers surrendered four earned runs in just 4.2 innings, a performance the Brewers will be hoping he can improve upon.

Analyzing the offensive capabilities, the Cardinals' lineup has been a mixed bag this season. While they rank 23rd in runs scored, they do show signs of life, especially at home.

Their recent form, however, has been less than stellar, dropping four of their last five games. The Brewers, on the other hand, have been a more consistent offensive unit, ranking 12th in the league in runs. They boast a respectable .242 team batting average and have shown the ability to string hits together, putting pressure on opposing pitchers.

When we look at the historical head-to-head matchups, the Cardinals have had the upper hand against the Brewers this season, holding a 7-5 record in their 12 contests.

This isn't just a recent trend; the Cardinals have generally performed well against Milwaukee, especially when playing at Busch Stadium. This home-field advantage, coupled with Gray's dominant form, sets a strong foundation for our betting strategy.

Considering the pitching matchup, Sonny Gray's exceptional form and his track record against the Brewers make him a significant factor.

His ability to stifle opposing offenses should give the Cardinals a distinct advantage. Tobias Myers, while talented, has struggled with consistency and the long ball, which could be exploited by the Cardinals' hitters, especially in their home park. The gap in pitching quality for this particular game is quite pronounced, favoring St.

Louis.

Therefore, the primary betting pick for this game is the St. Louis Cardinals on the Moneyline. Given Gray's dominance and Myers' recent struggles, the Cardinals present excellent value, especially if the odds reflect a tighter contest than the pitching matchup suggests.

For those looking for an additional angle, considering the Under on the Total Runs might also be prudent, especially with Gray pitching. While the Cardinals offense can be unpredictable, Gray's ability to limit runs should keep the score low, provided Myers doesn't have an absolute meltdown.

The current total is often set around 8.5 runs, and Gray's presence makes the Under a strong play.

In conclusion, all signs point to a Cardinals victory at home, primarily driven by the strength of their starting pitcher, Sonny Gray. Back the Redbirds on the moneyline for Friday's exciting showdown!