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A New Horizon for Breast Cancer: Enhertu Shows Groundbreaking Survival Benefit in HER2-low Metastatic Patients

  • Nishadil
  • October 07, 2025
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  • 1 minutes read
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A New Horizon for Breast Cancer: Enhertu Shows Groundbreaking Survival Benefit in HER2-low Metastatic Patients

In a monumental stride forward for cancer treatment, AstraZeneca and Daiichi Sankyo have announced groundbreaking results for their partnered antibody-drug conjugate (ADC), Enhertu (trastuzumab deruxtecan). The eagerly anticipated Phase III DESTINY-Breast04 trial has conclusively demonstrated that Enhertu offers a statistically significant and clinically meaningful overall survival (OS) and progression-free survival (PFS) benefit compared to physician’s choice chemotherapy in patients with HER2-low metastatic breast cancer.

This pivotal trial marks a new era in defining and treating HER2-low breast cancer, a subtype that was previously considered to be largely HER2-negative and thus not eligible for HER2-targeted therapies.

The successful outcomes from DESTINY-Breast04 not only validate Enhertu's efficacy in this patient population but also expand the scope of HER2-targeting beyond the traditional HER2-positive definition, potentially offering a lifeline to a significantly broader group of patients who previously had limited targeted treatment options.

The implications of these findings are profound.

For patients battling HER2-low metastatic breast cancer, Enhertu’s superior performance over standard chemotherapy represents a beacon of hope. It suggests a potential shift in the standard of care, providing an opportunity for improved long-term outcomes and quality of life. The data underscores Enhertu's mechanism as an antibody-drug conjugate, designed to deliver potent chemotherapy directly to cancer cells while minimizing systemic exposure.

Further details from the DESTINY-Breast04 trial are expected to be presented at an upcoming medical conference, and these results will form the basis for regulatory submissions around the world.

The collaboration between AstraZeneca and Daiichi Sankyo continues to yield remarkable advancements in oncology, reinforcing their commitment to developing innovative therapies that address unmet needs for cancer patients globally. This latest achievement with Enhertu is a testament to the power of targeted medicine and promises to reshape the treatment landscape for a devastating disease.

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