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Truist Ignites Excitement for Rapport Therapeutics (RAPP) with New 'Buy' Rating and $21 Price Target

  • Nishadil
  • September 17, 2025
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Truist Ignites Excitement for Rapport Therapeutics (RAPP) with New 'Buy' Rating and $21 Price Target

Rapport Therapeutics (NASDAQ: RAPP), a biopharmaceutical company focused on precision medicines for neurological disorders, is making significant waves in the market. The company, which recently went public in June at an IPO price of $17 per share, has just received a glowing endorsement from Truist Securities.

Analyst Asthika Goonewardene has initiated coverage on RAPP stock with a coveted 'Buy' rating, setting an optimistic price target of $21 per share.

This bullish outlook from Truist underscores a strong belief in Rapport's innovative pipeline and strategic direction. The analyst's confidence is rooted in a compelling combination of factors, primarily highlighting the strength of Rapport's management team and the groundbreaking potential of its lead candidate, RAP-219.

RAP-219 stands out as a beacon of hope for patients suffering from drug-resistant epilepsy.

This novel investigational drug targets the GABA-A receptor, a crucial player in neurological activity, by modulating specific alpha-2, alpha-3, and alpha-5 subunits. This selective approach is what truly differentiates RAP-219. Traditional benzodiazepines, while effective, often come with significant side effects due to their broad modulation of all GABA-A receptor subunits.

RAP-219 aims to offer a superior efficacy and tolerability profile by precisely targeting the subunits most relevant to seizure control and pain pathways, minimizing unwanted side effects.

The therapeutic potential of RAP-219 extends beyond epilepsy. The Truist report also points to its promise in other challenging neurological conditions, including peripheral neuropathic pain and bipolar disorder.

If successful, this broader applicability could significantly expand RAP-219's market reach and cement Rapport's position as a leader in precision neurology.

Goonewardene's analysis suggests that RAP-219's targeted mechanism could provide a much-needed alternative to existing treatments like lorazepam, clonazepam, and valium, which often fall short in managing drug-resistant cases or are plagued by dose-limiting side effects.

The ability to offer a safer, yet equally effective, treatment option could be transformative for patients and a substantial commercial win for Rapport.

As Rapport Therapeutics continues to advance RAP-219 through clinical development, the 'Buy' rating from Truist Securities serves as a powerful signal to investors.

It highlights the company's strong foundational assets, innovative scientific approach, and the potential for significant upside as it addresses critical unmet needs in neurological care. All eyes will now be on Rapport as it strives to deliver on the promise of its precision medicine pipeline.

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