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Healthcare Shorts Take a Breather, But Moderna Remains Under the Microscope

  • Nishadil
  • September 16, 2025
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  • 2 minutes read
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Healthcare Shorts Take a Breather, But Moderna Remains Under the Microscope

In a significant shift, short interest in the S&P 500 Healthcare sector saw a notable decline in August, signaling a potential easing of bearish sentiment. Data from S3 Partners reveals that short positions across the sector dropped by an impressive $1.1 billion, settling at a total of $90.9 billion for the month.

This retreat by short sellers indicates a cautious optimism or at least a reduced appetite for aggressive bets against healthcare stocks.

Drilling down into the specifics, the pharmaceutical, biotechnology, life sciences tools & services, and healthcare providers & services sub-sectors all experienced a decrease in short selling activity.

This broad-based decline suggests that investors are finding fewer compelling reasons to bet against these crucial segments of the healthcare industry. However, it wasn't a universal trend. The healthcare equipment & supplies and healthcare technology sectors actually saw an increase in short interest, indicating that some areas within healthcare are still attracting bearish attention.

Despite the overall sector-wide easing, one stock steadfastly held its position as the most shorted: Moderna (MRNA).

The biotech giant, a household name due to its pioneering work in mRNA vaccines, continues to be a magnet for short sellers. Its prominence on the list underscores persistent skepticism or concerns about its future growth trajectory and market valuation post-pandemic.

Beyond Moderna, the top five most shorted stocks by dollar value included healthcare behemoths such as UnitedHealth (UNH), Elevance Health (ELV), CVS Health (CVS), and Danaher (DHR).

These companies represent significant market capitalization, and their presence on the short list highlights that even industry leaders aren't immune to critical evaluations from bearish investors.

When examining short interest as a percentage of the float, Moderna's dominance is even more pronounced, with an impressive 14.65% of its shares available for trading held by short sellers.

Other notable mentions in this category include BioNTech (BNTX) at 9.07%, Viatris (VTRS) at 7.98%, Danaher (DHR) at 5.60%, and Regeneron Pharmaceuticals (REGN) at 3.59%. These figures offer a clearer picture of the intensity of bearish bets relative to the companies' publicly traded shares.

Interestingly, August also saw significant short covering, with investors closing out positions in stocks like UnitedHealth, Elevance Health, BioNTech, CVS Health, and even some in Moderna.

This covering activity contributed to the overall decrease in sector short interest. Conversely, new short positions were initiated or increased in Danaher, Regeneron Pharmaceuticals, and Intuitive Surgical (ISRG), suggesting a re-evaluation of opportunities within the healthcare landscape by some short-focused traders.

The August data paints a complex picture of the S&P 500 Healthcare sector.

While the broader trend points to an easing of bearish pressure, specific areas and individual stocks continue to attract substantial short interest. Investors will be keenly watching how these dynamics evolve in the coming months, especially as the economic landscape and healthcare policy continue to shift.

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