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Game Changer in Obesity Treatment: Novo Nordisk's Oral Wegovy Pill Achieves Remarkable 16.6% Weight Loss in Phase 3 Trial

  • Nishadil
  • September 19, 2025
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  • 2 minutes read
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Game Changer in Obesity Treatment: Novo Nordisk's Oral Wegovy Pill Achieves Remarkable 16.6% Weight Loss in Phase 3 Trial

The landscape of obesity treatment is on the cusp of a major transformation, thanks to groundbreaking results announced by Novo Nordisk. Their experimental high-dose oral version of semaglutide, widely known as the active ingredient in the blockbuster injectable drug Wegovy, has delivered truly impressive weight loss figures in a pivotal Phase 3 clinical trial.

This development signals a potential paradigm shift, offering a convenient pill format for managing chronic obesity, a condition affecting millions worldwide.

The OASIS 1 study, a comprehensive Phase 3 trial, evaluated the efficacy and safety of a 50mg oral semaglutide tablet in adults living with obesity or who are overweight with at least one weight-related comorbidity, but without type 2 diabetes.

The findings are nothing short of remarkable: participants receiving the oral semaglutide achieved an average body weight reduction of 15.1% over 68 weeks. When using a specific statistical approach that estimates the treatment effect if all participants remained on treatment, the weight loss figure soared to an astounding 16.6%.

These results stand in stark contrast to the placebo group, which saw a modest weight reduction of just 2.4%.

Such a significant difference underscores the profound therapeutic potential of this oral formulation. For many years, effective obesity medications often came with the inconvenience of injections. The prospect of achieving comparable, if not superior, results with a once-daily pill is a game-changer for patient adherence and accessibility.

Novo Nordisk’s injectable Wegovy (semaglutide 2.4mg) has already revolutionized the market, demonstrating excellent efficacy.

The oral version seeks to build on this success by addressing a critical patient preference: the desire for non-injectable treatment options. This could unlock a much wider patient population who might be hesitant to begin or maintain a self-injectable regimen, despite its proven benefits.

The safety profile observed in the OASIS 1 trial was consistent with that of the GLP-1 receptor agonist class.

Common adverse events were primarily gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation, generally mild to moderate and transient. These findings are reassuring, as they align with the well-established safety profile of semaglutide in its injectable forms.

The implications of these trial results extend beyond individual patient care.

For Novo Nordisk, this positions them strongly in a rapidly expanding and highly competitive obesity market, currently featuring strong contenders like Eli Lilly’s Mounjaro/Zepbound. An oral alternative to Wegovy could significantly expand their market share and solidify their leadership in the cardiometabolic space.

Looking ahead, Novo Nordisk has indicated its plans to file for regulatory approval for the oral semaglutide 50mg tablet in the United States and European Union later this year.

If approved, this oral medication could become a cornerstone of obesity management, offering healthcare providers and patients a powerful, convenient, and effective new tool in the ongoing battle against a complex chronic disease. This development truly represents a hopeful new chapter for those seeking effective long-term weight management solutions.

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